MODERN VIEWS ON CHRONIC POSTTRAUMATIC OSTEOMYELITIS

Cholakhyan Al'bert Vachaganovich, Postgraduate student, Saratov State Medical University named after V.I.Razumovsky(Saratov, 112 Kazachya Bolshaya str.), albert25@yandex.ru

616.71–002.2–07–089

In a review are introduced published results about origin, wide-spread position and social value of the chronic osteomyelitis. Modern possibilities of diagnostics, medical and surgical treatment of chronic posttraumatic osteomyelitis are the most full-fledged there. Authors are emphasized the importance of finding markers of the system inflammatory response in practice of surgeon, taking into consideration great forecasting features for possible reconstruction treatment.

osteomyelitis, soluble cell adhesion molecules, systemic inflammatory response syndrome, boneplastic operations.

1. Amiraslanov, YU. A. Sovremennyye printsipy khirurgicheskogo lecheniya khro-nicheskogo osteomiyelita / YU.A. Amiraslanov // Infektsii v khirurgii. – 2004. – № 2. – S. 8–13.
2. Nikitin, G. D. Khirurgicheskoye lecheniye osteomiyelita / G. D. Nikitin, A. V. Rak [i dr.]. – SPb. : Russkaya grafika, 2000. – 288 s.
3. Khatod, M. Outcomes in open tibia fractures: relationship between delay in treatment and infection / M.Khatod, M. J. Botte, D. B. Hoyt [et al.] // J. Trauma. – 2003. – Vol. 55 (5). – P. 949–954.
4. Carec, P. J. Diagnosis and Management of Osteomyelitis / P. J. Carec, L. M. Dickenson, J. I. Sack // American Family Physician. – 2001. – Vol. 63 (112). – P. 2413–2420.
5. Teleshova, Ye. B. Primeneniye sovremennykh biokompozitsionnykh materialov i antisepticheskikh preparatov v kompleksnom lechenii khronicheskogo posleopera-tsionnogo osteomiyelita i paraendoproteznoy infektsii : dis… kand. med. nauk / Teleshova Ye. B. – M., 2006. – 112 s.
6. Yeryukhin, I. A. Ekstremal'nyye sostoyaniya organizma: elementy teorii i prakticheskiye problemy / I.A.Yeryukhin, S. A. Shlyapnikov. – SPb. : Eskulap, 1997. – 296 s.
7. Donlan, R. M., Costerton, J. W. Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms // Clinical Microbiology Reviews. – 2002. – Vol. 15 (2). – P. 167–193.
8. Sidorenko, S. V. Rol' bakterial'nykh bioplenok v patologii cheloveka / S. V. Sidorenko // Infektsii v khirurgii. – 2004. – T. 2. – S. 16–20.
9. Roberts, M. E. Modeling Antibiotic Tolerance in Biofilms by Accounting for Nutri-ent Limitation / M. E. Roberts, P. S. Stewart // Antimicrob. Agents Chemother. – 2004. – Vol. 48. – R. 48–52.
10. Slobodskoy, A. B. Dopolnitel'nyye vozmozhnosti uluchsheniya krovoobrashche¬niya pri khronicheskom posttravmaticheskom osteomiyelite / A. B. Slobodskoy // Novyye tekhnologii v meditsine : sb. materialov nauch.-prakt. konf. – Kurgan, 2000. – CH. 2. – S. 57–58.
11. Pereslytskikh, P. F. Patogenez gematogennogo i posttravmaticheskogo osteo-miyelita (eksperimental'nyye i teoreticheskiye aspekty) / P. F. Pereslytskikh. – Irkutsk : RIO VSNTS SO RAMN, 2002. – 122 s.
12. Guchev, I. A. Antibakterial'naya terapiya netyazhelykh vnebol'nichnykh pnevmoniy / I. A. Guchev // Voyen.-med. zhurn. – 2003. – № 11. – S. 19–24
13. Nikitin, G. D. Plasticheskaya khirurgiya khronicheskikh i neyrotroficheskikh yazv / G. D. Nikitin, I. P. Kartashev, A. V. Rak [i dr.]. – SPb. : Russkaya grafika, OOO «Syuzhet», 2001. – 192 s.
14. Rak, A. V. Khronicheskiy osteomiyelit i yego lecheniye / A. V. Rak // Tezisy dokla-dov VII s"yezda travmatologov-ortopedov Rossii. – Novosibirsk, 2002. – T. 1. – S. 355–356.
15. Kaim, A. H. Imaging of chronic posttraumatic osteomyelitis / A. H. Kaim, T. Gross, G. K. von Schulthess // Eur. Radiol. – 2002. – № 5 (12). – P. 193–202.
16. Wagner, V. E. Trancriptome analysis of quorum-sensing regulation and virulens factor expression in Pseudomonas aeruginosa / V. E. Wagner, R. G. Gillis // Vaccine. – 2004. – Vol. 22. – P. 15–20.
17. Gonzales-Ordonez, A. J. Genetic markers of inflammation and sensivity to acti-vated protein C / A.J.Gonzales-Ordonez // Materialy kongressa po gemostaziolo-gii v Lyublyane. – 2004. – C. 183–184.
18. Totolyan, A. A. Kletki immunnoy sistemy / A. A. Totolyan, I. S. Freydlin. – SPb., 2000. – 231 s.
19. Drull, D. J. Human CRP Gene polymorphism Influences CRP Levels Implications for the Prediction and Pathogenesis of Coronary Heart Disease / D. J. Drull, N. Serrano, F. Zito [et al.] // Arterioscler. Thromb. Vasc. Biol. – 2003. – № 23. – P. 2063–2069.
20. Verstrepen, L. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme / L.Verstrepen // Cellular and molecular life sciences. – 2008. – Vol. 65 (19). – P. 2964–78.
21. Makatsariya, A. D. Sindrom sistemnogo vospalitel'nogo otveta v akusherstve / A. D. Makatsariya, V. O. Bitsadze, S. V. Akin'shina. – M. : Meditsinskoye informa-tsionnoye agentstvo, 2006. – 448 s.
22. Danesh, J. C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease / J. Danesh, D. Phil, J. G. Wheeler [et al.] // New Engl. J. Med. – 2004. – № 14. – P. 1387–1397.
23. Biasucci, L. M. CDC/AHA Workshop on markers of inflammation and cardiovas-cular disease: application to clinical and public health practice: clinical use of inflam-matory markers in patients with cardiovascular diseases: a background paper / L. M. Biasucci // Circulation. – 2004. – Vol. 110. – P. 560–567.
24. Korolova, O. S. Biomarkery v kardiologii: registratsiya vnutrisosudistogo vospa-leniya / O. S. Korolova // Farmateka. – 2007. – № 8/9. – S. 30–36.
25. Johnson, B. D. Serum amyloid A as a predictor of coronary artery diseases and car-diovascular outcome in women: the National Heart, Lung, and Blood institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE) / B. D. Johnson, K. E. Kip, O. C. Marroquin [et al.] // Circulation. – 2004. – Vol. 109. – P. 726–732.
26. Korzhenevskaya, K. V. Markery vospaleniya i osobennosti klinicheskogo te-cheniya ishemicheskoy bolezni serdtsa posle koronarnogo shuntirovaniya u patsiyen-tov s ostrym koronarnym sindromom bez pod"yema segmenta ST : avtoref. ... dis. kand. med. nauk / Korzhenevskaya K. V. – SPb., 2010. – 27 s.
27. Pasceri, V. Direct proinflammatory effect of C-reactive protein on human endotheli-al cells / V. Pasceri, J.T.Willerson, E. T. Yeh // Circulation. – 2000. – Vol. 102. – P. 2165–2168.
28. Schennach, H. Factors Influencing Serum Neopterin Concentrations in a Population of Blood Donors / H.Schennach // Clin. Chem. – 2002. – Vol. 48. – P. 643–645.
29. Gel'fand, B. R. Primeneniye aktivirovannogo proteina S v lechenii bol'nykh s tyazhelym sepsisom / B.R.Gel'fand // Infektsii v khirurgii. – 2004. – № 1. – S. 20–27.
30. Buhne, K. H. Imaging of posttraumatic osteomyelitis / K. H. Buhne, K. Bohndorf // Semin. Musculoskelet Radiol. – 2004. – Vol. 8 (3). – P. 199–204.
31. Lazzarini, L. Osteomyelitis in long bones / L. Lazzarini, J. T. Mader, J. H. Calhoum // J. Bone Jt. Surg. – 2004. – Vol. 86-A (10). – P. 2305–2318.
32. Mitina, YU. L. Komp'yuternaya tomografiya v diagnostike khronicheskogo retsidiviruyushchego osteomiyelita bedrennoy kosti : dis. ... kand. med. nauk / Mitina YU. L. – Kurgan, 2006. – 187 s.
33. Driscoll, K. E. TNF-alpha and MIP-2: Role in a particle-induced inflammation and regulation by oxidative stress / K. E. Driscoll // Toxicoll. Lett. – 2000. – Vol. 112–113. – P. 177–184.
34. Lutsevich, E. V. Lecheniye bol'nykh khronicheskim osteomiyelitom, oslozhnennym nalichiyem obshirnykh myagkotkanykh defektov nad osteomiyeliticheskim ochagom / E. V. Lutsevich // Sposob kontrolya protsessov osteogeneza i perestroyki v ochagakh kosteobrazovaniya : mater. k simpoziumu (Kurgan, 2000 g.). – Kurgan, 2000. – S. 180–181.
35. Parsons, B. Surgical management of chronic osteomyelitis / B. Parsons, E. Strauss // Am. J. Surg. – 2004. – Vol. 188 (1A Suppl). – P. 57–66.
36. Anipchenko, A. N. Khirurgicheskoye lecheniye osteomiyeliticheskikh defektov dlinnykh kostey konechnostey / A. N. Anipchenko // Khirurgiya. – 2007. – № 3. – C. 35–38.
37. Smith, I. M. The treatment of chronic osteomyelitis: a 10 year audit / I. M. Smith // J. Plast. Reconstr. Aesthet. Surg. – 2006. – Vol. 59 (1). – P. 11–15.
38. Omel'yanenko, N. P. Ispol'zovaniye demineralizovannogo kostnogo matriksa dlya vosstanovleniya povrezhdennykh dlinnykh kostey so znachitel'nymi defektami / N. P. Omel'yanenko // Vestnik travmatologii i ortopedii im. N. N. Priorova. – 2001. – № 1. – S. 53–56.
39. Blatun, L. A. Sovremennyye vozmozhnosti antimikrobnoy terapii ranevykh infektsiy myagkikh tkaney i osteomiyelita / L. A. Blatun // Antibiotiki i khimio-terapiya. – 2002. – № 47. – S. 31–36.
40. Ostanin, A. A. Khirurgicheskiy sepsis. Soobshcheniye 2. Effektivnost' immunoterapii rekombinantnym interleykinom 2 / A. A. Ostanin // Vestnik khirurgii im.
I. I. Grekova. – 2002. – T. 161, № 2. – S. 79–84.